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Contracts for Innovation: Industrial Human Relevant Drug Models (Innovate UK, AIM programme with NC3Rs)

Opens:
02.03.2026
Closes:
15.04.2026
Sectors:
Health & Life Sciences
Project Size:
up to £2 million

Innovate UK is launching a Contracts for Innovation competition to accelerate the development and commercialisation of non-animal methods that improve how the sector assesses pre-clinical pharmacokinetics (PK) and cardiovascular (CV) safety.

The competition is designed to support disruptive and innovative alternatives that can either be qualified for broad adoption, or strengthened so they are more applicable in real-world drug development workflows. Your Phase 1 work should demonstrate feasibility and clearly lay the groundwork for a credible Phase 2 plan, with the longer-term expectation that successful projects will help deliver models that meet the accuracy, cost, and throughput required to replace equivalent in vivo approaches.

Key dates

  • Competition opens: Monday 2 March 2026
  • Competition closes: Wednesday 15 April 2026 (11:00am UK time)
  • Applicants notified and feedback: 19 May 2026
  • Project start: 1 July 2026

 

Funding and project parameters

  • Total Phase 1 budget: up to £2 million
  • Number of awards: up to 12 contracts
  • Contract size: up to £200,000 total eligible costs per project
  • Duration: 6 to 9 months
  • Project end date: by 31 March 2027

 

Who can apply

Lead applicants can be an organisation of any size, including those based internationally, but the majority of project work and key deliverables must be completed in the UK. Subcontractors are permitted for specialist skills, and contracts are awarded to a single legal entity. You must intend to exploit the primary outputs of the project in the UK.

Scope and themes

Projects must focus on developing new approaches or further developing existing ones that can be deployed in drug development settings. The competition targets progress towards government aims to reduce animal use in:

  • Dedicated PK studies (dogs or non-human primates)
  • Dedicated cardiovascular safety studies (dogs or non-human primates) by 2030

The call welcomes a range of technologies and maturity levels, using a portfolio approach. Themes include, but are not limited to:

Pharmacokinetic studies

  • AI/ML-assisted PK/PD prediction improvements
  • Increasing exposure capabilities of in vitro models for PK/PD data
  • Better use of existing PK/PD data to expand modelling scope
  • Combinatorial in vitro and in silico approaches to reduce animal use

Cardiovascular safety

  • Improving robustness and reproducibility of in vitro assays
  • Enhancing predictive capacity of in silico cardiac safety models
  • Combining in vitro and in silico assays for improved accuracy
  • Integrating alternatives into a deployable, standardised framework for industry R&D
  • Supporting early screening through to mechanistic toxicity studies

 

How Inventya can help

Inventya supports organisations to compete effectively in high-demand Innovate UK calls by combining technical proposal expertise with commercial strategy and bid management discipline. For this competition, we can help you:

  • Scope fit and positioning: Translate your technology into a clear response to the PK or CV safety challenge, including the replacement case and how you contribute to 2030 targets.
  • Bid strategy and narrative: Build a compelling, assessor-friendly story that links technical feasibility to deployment, throughput, cost realism, and adoption potential in drug development settings.
  • Workplan and milestones: Develop a practical Phase 1 plan with strong evidence points, SMART milestones, and a payment schedule that aligns cleanly with the finance section.
  • Commercial and regulatory pathway: Strengthen route-to-market logic, early customer engagement, and regulatory engagement plans where required.
  • Compliance confidence: Reduce common eligibility risks, including VAT handling, subcontracting logic, and the R&D content expectations typical of procurement-style competitions.

Hurry and contact us now to get a headstart on the application.

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